Preformed Pd(II) Catalysts Based on Monoanionic [N,O] Ligands for Suzuki-Miyaura Cross-Coupling at Low Temperature

This paper describes the synthesis and catalytic testing of a palladium complex with 5-membered chelating [N,O] ligand, derived from condensation 2,6-diisopropylphenyl aniline maple lactone. catalyst was active towards Suzuki-Miyaura cross-coupling reaction, its activity optimised through selection base, solvent, loading temperature. The conditions are mild, occurring at room temperature over short timescale (1 h) using solvents considered to be ‘green’. A substrate scope then carried out in which showed good aryl bromides electron-withdrawing groups. across broad electron-donating high-withdrawing highest shown for weak also range boronic acids pinacol esters even featuring strong groups showing some activity. capable chlorides phenylboronic acid. more challenging reaction requires slightly elevated temperatures longer but is still mild compared similar examples literature.